Epigenetic aspects of X-chromosome dosage compensation.

@article{Park2001EpigeneticAO,
  title={Epigenetic aspects of X-chromosome dosage compensation.},
  author={Young Joo Park and Mitzi I. Kuroda},
  journal={Science},
  year={2001},
  volume={293 5532},
  pages={
          1083-5
        }
}
The X chromosomes of mammals and fruit flies exhibit unusual properties that have evolved to deal with the different dosages of X-linked genes in males (XY) and females (XX). The X chromosome dosage-compensation mechanisms discovered in these species are evolutionarily unrelated, but exhibit surprising parallels in their regulatory strategies. These features include the importance of noncoding RNAs, and epigenetic spreading of chromatin-modifying activities. Sex chromosomes have posed a… CONTINUE READING

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