Epigenetic and transcriptional regulation of IL4-induced CCL17 production in human monocytes and murine macrophages.

@article{Hsu2018EpigeneticAT,
  title={Epigenetic and transcriptional regulation of IL4-induced CCL17 production in human monocytes and murine macrophages.},
  author={Amy T Hsu and Tanya J Lupancu and Ming-Chin Lee and Andrew J. Fleetwood and Andrew D. Cook and John A Hamilton and Adrian Achuthan},
  journal={The Journal of biological chemistry},
  year={2018},
  volume={293 29},
  pages={
          11415-11423
        }
}
Interleukin 4 (IL4) is generally viewed as a Th2 cytokine capable of polarizing macrophages into an anti-inflammatory phenotype, whereas granulocyte macrophage-colony-stimulating factor (GM-CSF) is often viewed as a proinflammatory cytokine with part of this function due to its action on monocytes/macrophages. Paradoxically, these two cytokines act additively to enhance the in vitro differentiation of dendritic cells from precursors such as monocytes. One up-regulated marker of an IL4-polarized… CONTINUE READING