Epigenetic and microRNA-dependent control of cytochrome P450 expression: a gap between DNA and protein.

@article{Gomez2009EpigeneticAM,
  title={Epigenetic and microRNA-dependent control of cytochrome P450 expression: a gap between DNA and protein.},
  author={Alvin Gomez and Magnus Ingelman-Sundberg},
  journal={Pharmacogenomics},
  year={2009},
  volume={10 7},
  pages={1067-76}
}
Although pharmacogenetics has been instrumental in describing interindividual variations in drug metabolism, epigenetic factors offer another blanket of information that could give a more vivid picture and help in developing a more personalized therapy. The dynamic aspect of epigenetics could likewise provide more definite answers to the role of changing environmental factors in drug response: the bridge that connects the environment to the genome. In this review we discuss known epigenetic and… CONTINUE READING

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