Epigenetic and lncRNA regulation of cardiac pathophysiology.

  title={Epigenetic and lncRNA regulation of cardiac pathophysiology.},
  author={Ching-Pin Chang and Pei Yu Han},
  journal={Biochimica et biophysica acta},
  volume={1863 7 Pt B},
Our developmental studies provide an insight into the pathogenesis of heart failure in adults. These studies reveal a mechanistic link between fetal cardiomyocytes and pathologically stressed adult cardiomyocytes at the level of chromatin regulation. In embryos, chromatin-regulating factors within the cardiomyocytes respond to developmental signals to program cardiac gene expression to promote cell proliferation and inhibit premature cell differentiation. In the neonatal period, the activity of… CONTINUE READING
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