Epigenetic and genetic variations at the TNNT1 gene locus are associated with HDL-C levels and coronary artery disease.

@article{Guay2016EpigeneticAG,
  title={Epigenetic and genetic variations at the TNNT1 gene locus are associated with HDL-C levels and coronary artery disease.},
  author={Simon-Pierre Guay and C{\'e}cilia L{\'e}gar{\'e} and Diane Prud'homme Brisson and Patrick Mathieu and Yohan Boss{\'e} and Daniel Gaudet and Luigi Bouchard},
  journal={Epigenomics},
  year={2016},
  volume={8 3},
  pages={359-71}
}
AIM To assess whether epigenetic and genetic variations at the TNNT1 gene locus are associated with high-density lipoprotein cholesterol (HDL-C) and coronary artery disease (CAD). Patients, materials & methods: TNNT1 DNA methylation and c.-20G>A polymorphism were genotyped in subjects with and without familial hypercholesterolemia (FH). RESULTS Lower TNNT1 DNA methylation levels were independently associated with lower HDL-C levels and with the TNNT1 c.-20G>A polymorphism. In FH men, carriers… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-8 of 8 extracted citations

Similar Papers

Loading similar papers…