Epigenetic and genetic alterations of p33ING1b in ovarian cancer.


p33ING1b is a candidate tumor suppressor gene and a nuclear protein. We investigated whether genetic and epigenetic mechanisms affect p33ING1b expression in ovarian cancer thus contributing toward its pathogenesis. A total of 111 ovarian cancers collected from Beijing and Hong Kong were used for this study. Weak or negative p33ING1b protein expression was… (More)


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@article{Shen2005EpigeneticAG, title={Epigenetic and genetic alterations of p33ING1b in ovarian cancer.}, author={Dan-hua Shen and Kelvin Yuen-kwong Chan and U S Khoo and Hextan Yuen-Sheung Ngan and Wei-cheng Xue and Pui-Man Chiu and Philip P Ip and Annie Nga-Yin Cheung}, journal={Carcinogenesis}, year={2005}, volume={26 4}, pages={855-63} }