Epigenetic and disease targets by polyphenols.

  title={Epigenetic and disease targets by polyphenols.},
  author={Min-Hsiung Pan and Ching-Shu Lai and J. S. Wu and Chitang Ho},
  journal={Current pharmaceutical design},
  volume={19 34},
An epigenetic change is defined as an alteration in gene expression that does not involve a change in the DNA sequence. Epigenetic modifications, including DNA methylation, histone modification (acetylation, methylation and phosphorylation) and miRNA, are critical for regulating developmental events. However, aberrant epigenetic mechanisms may lead to pathological consequences such as cardiovascular disease (CAD), neurodegenerative disease, obesity, metabolic disorder, bone and skeletal… CONTINUE READING
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