Epigenetic analysis of childhood acute lymphoblastic leukemia.

@article{Dunwell2009EpigeneticAO,
  title={Epigenetic analysis of childhood acute lymphoblastic leukemia.},
  author={Thomas Lawson Dunwell and Luke B. Hesson and Tatiana Vasilievna Pavlova and Veronika Zabarovska and Vladimir Kashuba and Daniel R. Catchpoole and Raffaella Chiaramonte and Anna Teresa Brini and Michael J Griffiths and Eamonn R Maher and Eugene R. Zabarovsky and Farida Latif},
  journal={Epigenetics},
  year={2009},
  volume={4 3},
  pages={
          185-93
        }
}
We used a chromosome 3 wide NotI microarray for identification of epigenetically inactivated genes in childhood acute lymphoblastic leukemia (ALL). Three novel genes demonstrated frequent methylation in childhood ALL. PPP2R3A (protein phosphatase 2, regulatory subunit B", alpha) was frequently methylated in T (69%) and B (82%)-ALL. Whilst FBLN2 (fibulin 2) and THRB (thyroid hormone receptor, beta) showed frequent methylation in B-ALL (58%; 56% respectively), but were less frequently methylated… CONTINUE READING
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