Epigenetic alterations in ultraviolet radiation-induced skin carcinogenesis: interaction of bioactive dietary components on epigenetic targets.

@article{Katiyar2012EpigeneticAI,
  title={Epigenetic alterations in ultraviolet radiation-induced skin carcinogenesis: interaction of bioactive dietary components on epigenetic targets.},
  author={Santosh Kumar Katiyar and Tripti Singh and Ram Pravesh Prasad and Qian Sun and Mudit Vaid},
  journal={Photochemistry and photobiology},
  year={2012},
  volume={88 5},
  pages={1066-74}
}
The importance of epigenetic alterations in the development of various diseases including the cancers has been realized. As epigenetic changes are reversible heritable changes, these can be utilized as an effective strategy for the prevention of cancers. DNA methylation is the most characterized epigenetic mechanism that can be inherited without changing the DNA sequence. Although limited available data suggest that silencing of tumor suppressor genes in ultraviolet (UV) radiation-exposed… CONTINUE READING
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Epigal - locatechin3gallate reactivates silenced tumor suppressor genes by reducing DNA methylation and increasing histones acetylation in human skin cancer cells

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