Epigenetic alterations in human pluripotent stem cells: a tale of two cultures.

  title={Epigenetic alterations in human pluripotent stem cells: a tale of two cultures.},
  author={Anton Wutz},
  journal={Cell stem cell},
  volume={11 1},
Human somatic cells can be reprogrammed into induced pluripotent stem cells (hiPSCs) with wide lineage differentiation potential in culture. However, reprogramming and long-term culture can also induce abnormalities in these pluripotent cells. This minireview discusses recent studies that have identified changes in imprinted gene expression and erosion of X chromosome inactivation in female hiPSCs and how understanding the sources and consequences of epigenetic variability in hiPSCs will impact… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 3 times. VIEW TWEETS


Publications citing this paper.
Showing 1-10 of 14 extracted citations


Publications referenced by this paper.
Showing 1-10 of 50 references

Derivation conditions determine X-reactivation status in female human induced pluripotent stem cells

K. Tomoda, K. Takahashi, +8 authors M.P
Cell Stem Cell 11, • 2012
View 14 Excerpts
Highly Influenced

Human embryonic stem cells with biological and epigenetic characteristics similar to those of mouse ESCs.

Proceedings of the National Academy of Sciences of the United States of America • 2010
View 10 Excerpts
Highly Influenced

Naive and primed pluripotent states.

Cell stem cell • 2009
View 4 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…