Epigenetic alterations in human pluripotent stem cells: a tale of two cultures.

@article{Wutz2012EpigeneticAI,
  title={Epigenetic alterations in human pluripotent stem cells: a tale of two cultures.},
  author={Anton Wutz},
  journal={Cell stem cell},
  year={2012},
  volume={11 1},
  pages={9-15}
}
Human somatic cells can be reprogrammed into induced pluripotent stem cells (hiPSCs) with wide lineage differentiation potential in culture. However, reprogramming and long-term culture can also induce abnormalities in these pluripotent cells. This minireview discusses recent studies that have identified changes in imprinted gene expression and erosion of X chromosome inactivation in female hiPSCs and how understanding the sources and consequences of epigenetic variability in hiPSCs will impact… CONTINUE READING
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