Epigenetic activation of the drug transporter OCT2 sensitizes renal cell carcinoma to oxaliplatin

  title={Epigenetic activation of the drug transporter OCT2 sensitizes renal cell carcinoma to oxaliplatin},
  author={Y. Liu and X. Zheng and Qinqin Yu and H. Wang and F. Tan and Qianying Zhu and Lingmin Yuan and Huidi Jiang and L. Yu and S. Zeng},
  journal={Science Translational Medicine},
  pages={348ra97 - 348ra97}
  • Y. Liu, X. Zheng, +7 authors S. Zeng
  • Published 2016
  • Biology, Medicine
  • Science Translational Medicine
  • The expression of drug transporter OCT2 is suppressed in renal cell carcinoma, and targeting this pathway sensitizes the tumor to oxaliplatin. Opening a door into cancer cells Renal cell carcinoma is a common cancer that is often resistant to chemotherapy. To address this, Liu et al. investigated the role of OCT2, a protein that normally transports oxaliplatin, a common chemotherapy drug, into cells. The authors found that OCT2 was epigenetically silenced in renal cancer and figured out the… CONTINUE READING
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