Epigenetic activation of human kallikrein 13 enhances malignancy of lung adenocarcinoma by promoting N-cadherin expression and laminin degradation.

@article{Chou2011EpigeneticAO,
  title={Epigenetic activation of human kallikrein 13 enhances malignancy of lung adenocarcinoma by promoting N-cadherin expression and laminin degradation.},
  author={Ruey Hwang Chou and Sheng-Chieh Lin and Hui-Chin Wen and C Wu and W W Chang},
  journal={Biochemical and biophysical research communications},
  year={2011},
  volume={409 3},
  pages={442-7}
}
The tissue kallikrein (KLK) family contains 15 genes (KLK1-KLK15) tandemly arranged on chromosome 19q13.4 that forms the largest cluster of contiguous protease genes in the human genome. Here, we provide mechanistic evidence showing that the expression of KLK13, one of the most recently identified family members, is significantly up-regulated in metastatic lung adenocarcinoma. Whilst overexpression of KLK13 resulted in an increase in malignant cell behavior, knockdown of its endogenous gene… CONTINUE READING

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