Epigenetic Upregulation of lncRNAs at 13q14.3 in Leukemia Is Linked to the In Cis Downregulation of a Gene Cluster That Targets NF-kB

@inproceedings{Garding2013EpigeneticUO,
  title={Epigenetic Upregulation of lncRNAs at 13q14.3 in Leukemia Is Linked to the In Cis Downregulation of a Gene Cluster That Targets NF-kB},
  author={Angela Garding and Nupur Gupta Bhattacharya and R. James Claus and Melanie Ruppel and Cordula Tschuch and Katharina Filarsky and Irina S Idler and Manuela Zucknick and Ma{\"i}wen Caudron-Herger and Christopher C. Oakes and Verena Julia Fleig and Ioanna Keklikoglou and Danilo Allegra and Leticia Salazar Serra and Sudhir Thakurela and Vijay Tiwari and Dieter Weichenhan and Axel Benner and Bernhard Radlwimmer and H. Zentgraf and Stefan Wiemann and Karsten Rippe and Christoph Plass and Hartmut D{\"o}hner and Peter Lichter and Stephan Stilgenbauer and Daniel Mertens},
  booktitle={PLoS genetics},
  year={2013}
}
Non-coding RNAs are much more common than previously thought. However, for the vast majority of non-coding RNAs, the cellular function remains enigmatic. The two long non-coding RNA (lncRNA) genes DLEU1 and DLEU2 map to a critical region at chromosomal band 13q14.3 that is recurrently deleted in solid tumors and hematopoietic malignancies like chronic lymphocytic leukemia (CLL). While no point mutations have been found in the protein coding candidate genes at 13q14.3, they are deregulated in… CONTINUE READING

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