Epigenetic Transgenerational Actions of Endocrine Disruptors and Male Fertility

@article{Anway2005EpigeneticTA,
  title={Epigenetic Transgenerational Actions of Endocrine Disruptors and Male Fertility},
  author={Matthew D. Anway and Andrea S. Cupp and Mehmet Uzumcu and Michael K. Skinner},
  journal={Science},
  year={2005},
  volume={308},
  pages={1466 - 1469}
}
Transgenerational effects of environmental toxins require either a chromosomal or epigenetic alteration in the germ line. [...] Key Result Transient exposure of a gestating female rat during the period of gonadal sex determination to the endocrine disruptors vinclozolin (an antiandrogenic compound) or methoxychlor (an estrogenic compound) induced an adult phenotype in the F1 generation of decreased spermatogenic capacity (cell number and viability) and increased incidence of male infertility.Expand
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  • 2007
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The epigenetic mechanism is hypothesized to involve the induction of new imprinted-like DNA sequences in the germ-line to transgenerationally transmit disease phenotypes and offers new insights into novel diagnostic and therapeutic strategies.
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TLDR
The epigenetic effects of alcohol, assisted reproductive techniques, cancer therapy, and endocrine disruptors observed in humans and in animal studies are described, with special attention being paid to imprinted genes.
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TLDR
The suggestion that environmental factors can reprogram early development to induce epigenetic transgenerational phenotypes is a new paradigm in biology that will open new avenues for studies in disease etiology, reproduction and evolutionary biology.
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TLDR
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TLDR
It is suggested that embryonic exposure to environmental endocrine disruptors induces transgenerational epigenetic deregulation of expression of microRNAs affecting key regulatory pathways of germ cells differentiation, as determined by global maps of cytosine methylation.
Transgenerational and Epigenetic Impacts of Environmental Exposures in Male Reproduction
TLDR
A brief review of how epigenetics can act transgenerationally through the male germline is hereby presented.
Endocrine disruptor induction of epigenetic transgenerational inheritance of disease
  • M. Skinner
  • Medicine, Biology
    Molecular and Cellular Endocrinology
  • 2014
TLDR
The current review will describe the previous studies and endocrine disruptors shown to promote the epigenetic transgenerational inheritance of disease.
Germline and reproductive tract effects intensify in male mice with successive generations of estrogenic exposure
TLDR
The data suggest that male sensitivity to environmental estrogens is increased by successive generations of exposure, and that multiple generations of Exposure not only exacerbate germ cell exposure effects, but also increase the incidence and severity of reproductive tract abnormalities.
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