Epigenetic Transgenerational Actions of Endocrine Disruptors and Male Fertility

  title={Epigenetic Transgenerational Actions of Endocrine Disruptors and Male Fertility},
  author={M. D. Anway and A. Cupp and M. Uzumcu and M. Skinner},
  pages={1466 - 1469}
  • M. D. Anway, A. Cupp, +1 author M. Skinner
  • Published 2005
  • Biology, Medicine
  • Science
  • Transgenerational effects of environmental toxins require either a chromosomal or epigenetic alteration in the germ line. [...] Key Result Transient exposure of a gestating female rat during the period of gonadal sex determination to the endocrine disruptors vinclozolin (an antiandrogenic compound) or methoxychlor (an estrogenic compound) induced an adult phenotype in the F1 generation of decreased spermatogenic capacity (cell number and viability) and increased incidence of male infertility.Expand Abstract
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