Epigenetic Silencing of Somatostatin in Gastric Cancer

  title={Epigenetic Silencing of Somatostatin in Gastric Cancer},
  author={Kaya Jackson and Mohammed Soutto and Dunfa Peng and Tianling Hu and Dana Marshal and Wael El-Rifai},
  journal={Digestive Diseases and Sciences},
Somatostatin (SST), a primary inhibitor of gastrin-stimulated gastric acid secretion, has potent antitumor and anti-secretory activity in several human cancers. This study was performed to investigate the SST gene expression levels and possible epigenetic mechanisms that regulate expression of SST in gastric adenocarcinomas. Quantitative real-time (RT)-PCR and quantitative bisulfite pyrosequencing were used to study primary gastric cancer tissue samples and cell lines. Quantitative RT-PCR… CONTINUE READING


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