• DOI:10.1126/SCIENCE.1063443
Corpus ID: 17089710

Epigenetic Reprogramming in Mammalian Development

@article{Reik2001EpigeneticRI,
  title={Epigenetic Reprogramming in Mammalian Development},
  author={W. Reik and W. Dean and J. Walter},
  journal={Science},
  year={2001},
  volume={293},
  pages={1089 - 1093}
}

• W. Reik, W. Dean, J. Walter
• Published 2001
• Biology, Medicine
• Science

DNA methylation is a major epigenetic modification of the genome that regulates crucial aspects of its function. Genomic methylation patterns in somatic differentiated cells are generally stable and heritable. However, in mammals there are at least two developmental periods—in germ cells and in preimplantation embryos—in which methylation patterns are reprogrammed genome wide, generating cells with a broad developmental potential. Epigenetic reprogramming in germ cells is critical for… Expand

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