Epigenetic Regulation of Vascular Smooth Muscle Cell Function in Atherosclerosis

@article{Findeisen2013EpigeneticRO,
  title={Epigenetic Regulation of Vascular Smooth Muscle Cell Function in Atherosclerosis},
  author={Hannes M. Findeisen and Florian K Kahles and Dennis Bruemmer},
  journal={Current Atherosclerosis Reports},
  year={2013},
  volume={15},
  pages={1-8}
}
Epigenetics involve heritable and acquired changes in gene transcription that occur independently of the DNA sequence. Epigenetic mechanisms constitute a hierarchic upper-level of transcriptional control through complex modifications of chromosomal components and nuclear structures. These modifications include, for example, DNA methylation or post-translational modifications of core histones; they are mediated by various chromatin-modifying enzymes; and ultimately they define the accessibility… CONTINUE READING
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