Epigenetic Regulation of Tissue-Type Plasminogen Activator in Human Brain Tissue and Brain-Derived Cells

Abstract

The serine protease tissue-type plasminogen activator (t-PA) is involved in both vital physiological brain processes, such as synaptic plasticity, and pathophysiological conditions, such as neurodegeneration and ischemic stroke. Recent data suggest that epigenetic mechanisms play an important role in the regulation of t-PA in human endothelial cells… (More)
DOI: 10.4137/GRSB.S30241

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@inproceedings{Olsson2016EpigeneticRO, title={Epigenetic Regulation of Tissue-Type Plasminogen Activator in Human Brain Tissue and Brain-Derived Cells}, author={M. Charlotte Olsson and Karin Hultman and Sylvie Dunoyer-Geindre and Maurice A. Curtis and Richard L. M. Faull and Egbert K. O. Kruithof and Christina Jern}, booktitle={Gene regulation and systems biology}, year={2016} }