Epigenetic Regulation of Stem Cell Differentiation

  title={Epigenetic Regulation of Stem Cell Differentiation},
  author={Hao Wu and Yi Sun},
  journal={Pediatric Research},
Stem cells undergo extensive self-renewal and have the capacity to differentiate along multiple cell lineages. Progression from stem cells into differentiated progeny requires long-lasting changes in gene expression. Epigenetic mechanisms, including DNA methylation, histone modifications, and non-coding RNA-mediated regulatory events, are essential to controlling the heritable cellular memory of gene expression during development. Recent studies on cell fate specification of embryonic and adult… CONTINUE READING