Epigenetic Regulation of Endothelial Lineage Committed Genes in Pro-Angiogenic Hematopoietic and Endothelial Progenitor Cells

  title={Epigenetic Regulation of Endothelial Lineage Committed Genes in Pro-Angiogenic Hematopoietic and Endothelial Progenitor Cells},
  author={Kisho Ohtani and Georgios J. Vlachojannis and Masamichi Koyanagi and Jes-Niels Boeckel and Carmen Urbich and Ruxandra Farcas and Halvard Bonig and Victor E. Marquez and Andreas M. Zeiher and Stefanie Dimmeler},
  journal={Circulation Research},
Rationale: Proangiogenic hematopoietic and endothelial progenitor cells (EPCs) contribute to postnatal neovascularization, but the mechanisms regulating differentiation to the endothelial lineage are unclear. Objective: To elucidate the epigenetic control of endothelial gene expression in proangiogenic cells and EPCs. Methods and Results: Here we demonstrate that the endothelial nitric oxide synthase (eNOS) promoter is epigenetically silenced in proangiogenic cells (early EPCs), CD34+ cells… 

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