Epigenetic Regulation of Cell Type–Specific Expression Patterns in the Human Mammary Epithelium

@inproceedings{Maruyama2011EpigeneticRO,
  title={Epigenetic Regulation of Cell Type–Specific Expression Patterns in the Human Mammary Epithelium},
  author={Reo Maruyama and Sibgat A. Choudhury and Adam P Kowalczyk and Marina O Bessarabova and Bryan Beresford-Smith and Thomas E Conway and Antony Kaspi and Zhenhua Wu and Tatiana Nikolskaya and Vanessa F. Merino and Pang-Kuo Lo and Xiaole Shirley Liu and Yuri Nikolsky and Saraswati V. Sukumar and Izhak Haviv and Korn{\'e}lia Poly{\'a}k},
  booktitle={PLoS genetics},
  year={2011}
}
Differentiation is an epigenetic program that involves the gradual loss of pluripotency and acquisition of cell type-specific features. Understanding these processes requires genome-wide analysis of epigenetic and gene expression profiles, which have been challenging in primary tissue samples due to limited numbers of cells available. Here we describe the application of high-throughput sequencing technology for profiling histone and DNA methylation, as well as gene expression patterns of normal… CONTINUE READING

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