Epigenetic Priming of Memory Updating during Reconsolidation to Attenuate Remote Fear Memories

@article{Grff2014EpigeneticPO,
  title={Epigenetic Priming of Memory Updating during Reconsolidation to Attenuate Remote Fear Memories},
  author={Johannes Gr{\"a}ff and Nadine F. Joseph and Meryl E. Horn and Alireza Samiei and J. R. Meng and Jinsoo Seo and Damien Rei and Adam W. Bero and Trongha X. Phan and Florence S. Wagner and Edward J Holson and Jinbin Xu and Jianjun Sun and Rachael Lee Neve and Robert H. Mach and Stephen J. Haggarty and Li-Huei Tsai},
  journal={Cell},
  year={2014},
  volume={156},
  pages={261-276}
}
Traumatic events generate some of the most enduring forms of memories. Despite the elevated lifetime prevalence of anxiety disorders, effective strategies to attenuate long-term traumatic memories are scarce. The most efficacious treatments to diminish recent (i.e., day-old) traumata capitalize on memory updating mechanisms during reconsolidation that are initiated upon memory recall. Here, we show that, in mice, successful reconsolidation-updating paradigms for recent memories fail to… CONTINUE READING
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