Epigenetic Plasticity Drives Adipogenic and Osteogenic Differentiation of Marrow-derived Mesenchymal Stem Cells.

@article{Meyer2016EpigeneticPD,
  title={Epigenetic Plasticity Drives Adipogenic and Osteogenic Differentiation of Marrow-derived Mesenchymal Stem Cells.},
  author={Mark B. Meyer and Nancy A Benkusky and Buer Sen and Janet E. Rubin and John Wesley Pike},
  journal={The Journal of biological chemistry},
  year={2016},
  volume={291 34},
  pages={17829-47}
}
Terminal differentiation of multipotent stem cells is achieved through a coordinated cascade of activated transcription factors and epigenetic modifications that drive gene transcription responsible for unique cell fate. Within the mesenchymal lineage, factors such as RUNX2 and PPARγ are indispensable for osteogenesis and adipogenesis, respectively. We therefore investigated genomic binding of transcription factors and accompanying epigenetic modifications that occur during osteogenic and… CONTINUE READING
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