Epigenetic Modifications of Cytosine: Biophysical Properties, Regulation, and Function in Mammalian DNA.

@article{Hardwick2018EpigeneticMO,
  title={Epigenetic Modifications of Cytosine: Biophysical Properties, Regulation, and Function in Mammalian DNA.},
  author={Jack S Hardwick and Andrew N. Lane and Tom Brown},
  journal={BioEssays : news and reviews in molecular, cellular and developmental biology},
  year={2018},
  volume={40 3}
}
To decode the function and molecular recognition of several recently discovered cytosine derivatives in the human genome - 5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxylcytosine - a detailed understanding of their effects on the structural, chemical, and biophysical properties of DNA is essential. Here, we review recent literature in this area, with particular emphasis on features that have been proposed to enable the specific recognition of modified cytosine bases by DNA-binding… CONTINUE READING