Epigenetic Modification Agents Improve Genomic Methylation Reprogramming in Porcine Cloned Embryos

@inproceedings{Huan2014EpigeneticMA,
  title={Epigenetic Modification Agents Improve Genomic Methylation Reprogramming in Porcine Cloned
Embryos},
  author={Yan Jun Huan and Jiang Zhu and Hong Wang and Zhan Feng Wu and Ji Guang Zhang and Bing Xie and Jing Li and Qing Ran Kong and Zhong Hua Liu and Hong He},
  booktitle={The Journal of reproduction and development},
  year={2014}
}
Incomplete DNA methylation reprogramming in cloned embryos leads to low cloning efficiency. Our previous studies showed that the epigenetic modification agents 5-aza-2'-deoxycytidine (5-aza-dC) or trichostatin A (TSA) could enhance the developmental competence of porcine cloned embryos. Here, we investigated genomic methylation dynamics and specific gene expression levels during early embryonic development in pigs. In this study, our results showed that there was a typical wave of DNA… CONTINUE READING
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