Epigenetic Mechanisms Involved in Huntington's Disease Pathogenesis.

@article{Glajch2015EpigeneticMI,
  title={Epigenetic Mechanisms Involved in Huntington's Disease Pathogenesis.},
  author={Kelly E. Glajch and G. Sadri-Vakili},
  journal={Journal of Huntington's disease},
  year={2015},
  volume={4 1},
  pages={
          1-15
        }
}
Transcriptional dysregulation is an early event and may be an important pathological mechanism in Huntington's disease (HD). However, the exact process that leads to alterations in gene expression in HD is not clear. One potential mechanism underlying transcriptional abnormalities in HD may be epigenetic alterations which regulate gene expression without changing the DNA sequence. Previous work has demonstrated that epigenetic marks, such as DNA methylation and post-translational modifications… Expand
Epigenetic Regulation in Neurodegenerative Diseases
Contribution of Neuroepigenetics to Huntington’s Disease
Epigenetic mechanisms in amyotrophic lateral sclerosis: A short review
Epigenetic Changes in Neurodegenerative Diseases
Epigenetics of Huntington's Disease.
Hippo Signaling Pathway Dysregulation in Human Huntington’s Disease Brain and Neuronal Stem Cells
...
1
2
3
4
...

References

SHOWING 1-10 OF 166 REFERENCES
Transcription, Epigenetics and Ameliorative Strategies in Huntington’s Disease: a Genome-Wide Perspective
Transcriptional signatures in Huntington's disease
  • J. Cha
  • Biology, Medicine
  • Progress in Neurobiology
  • 2007
Modulation of nucleosome dynamics in Huntington's disease.
HDAC inhibition imparts beneficial transgenerational effects in Huntington's disease mice via altered DNA and histone methylation
Epigenetic mechanisms in neurological disease
Genome-Wide Histone Acetylation Is Altered in a Transgenic Mouse Model of Huntington's Disease
The HDAC inhibitor 4b ameliorates the disease phenotype and transcriptional abnormalities in Huntington's disease transgenic mice
Targeting H3K4 trimethylation in Huntington disease
...
1
2
3
4
5
...