Epigenetic Mechanisms Governing Innate Inflammatory Responses.


Toll-like receptors (TLRs) are major receptors of the host innate immune system that recognize conserved pathogen-associated molecular patterns (PAMPs) of invading microbes. Activation of TLR signaling culminates in the expression of multiple genes in a coordinate and kinetically defined manner. In this review, we summarize the current studies describing the chromatin landscape of TLR-responsive inflammatory genes and how changes to this chromatin landscape govern cell type-specific and temporal gene expression. We further elaborate classical endotoxin tolerance and epigenetic mechanisms controlling tolerance and interferon priming effects on inflammatory promoters.

DOI: 10.1089/jir.2016.0003

Cite this paper

@article{Perkins2016EpigeneticMG, title={Epigenetic Mechanisms Governing Innate Inflammatory Responses.}, author={Darren J. Perkins and Mira C. Patel and Jorge C G Blanco and Stefanie N. Vogel}, journal={Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research}, year={2016}, volume={36 7}, pages={454-61} }