Epigenetic Landscapes Explain Partially Reprogrammed Cells and Identify Key Reprogramming Genes

@inproceedings{Lang2013EpigeneticLE,
  title={Epigenetic Landscapes Explain Partially Reprogrammed Cells and Identify Key Reprogramming Genes},
  author={Alex H. Lang and Hu Li and James J. Collins and Pankaj Mehta},
  booktitle={PLoS Computational Biology},
  year={2013}
}
A common metaphor for describing development is a rugged "epigenetic landscape" where cell fates are represented as attracting valleys resulting from a complex regulatory network. Here, we introduce a framework for explicitly constructing epigenetic landscapes that combines genomic data with techniques from spin-glass physics. Each cell fate is a dynamic attractor, yet cells can change fate in response to external signals. Our model suggests that partially reprogrammed cells are a natural… CONTINUE READING

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