Epigenetic Involvement in Hutchinson-Gilford Progeria Syndrome: A Mini-Review

@article{Arancio2014EpigeneticII,
  title={Epigenetic Involvement in Hutchinson-Gilford Progeria Syndrome: A Mini-Review},
  author={W. Arancio and G. Pizzolanti and S. Genovese and M. Pitrone and C. Giordano},
  journal={Gerontology},
  year={2014},
  volume={60},
  pages={197 - 203}
}
Hutchinson-Gilford progeria syndrome (HGPS) is a rare human genetic disease that leads to a severe premature ageing phenotype, caused by mutations in the LMNA gene. The LMNA gene codes for lamin-A and lamin-C proteins, which are structural components of the nuclear lamina. HGPS is usually caused by a de novo C1824T mutation that leads to the accumulation of a dominant negative form of lamin-A called progerin. Progerin also accumulates physiologically in normal ageing cells as a rare splicing… Expand
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TACG_A_273525 279..295
Department of Translational Research and of New Surgical and Medical Technologies, University of Pisa, Pisa, Italy Abstract: Premature-ageing syndromes are a heterogeneous group of rare geneticExpand
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Bioinformatics analyses of the network of interactions of the LMNA gene and transcripts suggest particular relevance of epigenetic modifiers and adenosine triphosphate (ATP)-dependent chromatin remodelers in HGPS. Expand
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