Epigenetic Inactivation of Notch-Hes Pathway in Human B-Cell Acute Lymphoblastic Leukemia

@inproceedings{Kuang2013EpigeneticIO,
  title={Epigenetic Inactivation of Notch-Hes Pathway in Human B-Cell Acute Lymphoblastic Leukemia},
  author={S S Kuang and Zhihong Fang and Patrick A. Zweidler-McKay and Hui Yang and Yue Wei and Emilio A. Gonzalez-Cervantes and Yanis A. Boumber and Guillermo Garcia-Manero},
  booktitle={PloS one},
  year={2013}
}
The Notch pathway can have both oncogenic and tumor suppressor roles, depending on cell context. For example, Notch signaling promotes T cell differentiation and is leukemogenic in T cells, whereas it inhibits early B cell differentiation and acts as a tumor suppressor in B cell leukemia where it induces growth arrest and apoptosis. The regulatory… CONTINUE READING