Epigenetic Downregulation of Scn3a Expression by Valproate: a Possible Role in Its Anticonvulsant Activity

@article{Tan2016EpigeneticDO,
  title={Epigenetic Downregulation of Scn3a Expression by Valproate: a Possible Role in Its Anticonvulsant Activity},
  author={Na-Na Tan and Hui-Ling Tang and Guo-Wang Lin and Yong-hong Chen and Ping Lu and Hai-jun Li and Mei-Mei Gao and Qi-Hua Zhao and Yong-hong Yi and Wei-Ping Liao and Yue-Sheng Long},
  journal={Molecular Neurobiology},
  year={2016},
  volume={54},
  pages={2831-2842}
}
Upregulation of sodium channel SCN3A expression in epileptic tissues is known to contribute to enhancing neuronal excitability and the development of epilepsy. Therefore, certain strategies to reduce SCN3A expression may be helpful for seizure control. Here, we reveal a novel role of valproate (VPA) in the epigenetic downregulation of Scn3a expression. We found that VPA, instead of carbamazepine (CBZ) and lamotrigine (LTG), could significantly downregulate Scn3a expression in mouse Neuro-2a… CONTINUE READING
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The role of fat mass and obesity-associated gene (FTO) in obesity—an overview

A Zdrojowy-Welna, M Tupikowska, K Kolackov, G BednarekTupikowska
  • Endokrynol Pol 65:224–231
  • 2014
VIEW 1 EXCERPT

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