Epigenetic Determinants of Cancer.

  title={Epigenetic Determinants of Cancer.},
  author={Stephen B. Baylin and Peter A. Jones},
  journal={Cold Spring Harbor perspectives in biology},
  volume={8 9}
SUMMARYEpigenetic changes are present in all human cancers and are now known to cooperate with genetic alterations to drive the cancer phenotype. These changes involve DNA methylation, histone modifiers and readers, chromatin remodelers, microRNAs, and other components of chromatin. Cancer genetics and epigenetics are inextricably linked in generating the malignant phenotype; epigenetic changes can cause mutations in genes, and, conversely, mutations are frequently observed in genes that modify… CONTINUE READING
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