Epigenetic DNA methylation of antioxidative stress regulator NRF2 in human prostate cancer.

  title={Epigenetic DNA methylation of antioxidative stress regulator NRF2 in human prostate cancer.},
  author={Tin Oo Khor and Francisco C. Fuentes and Limin Shu and Ximena Paredes-Gonzalez and Anne Yuqing Yang and Yue Liu and Dominic J. Smiraglia and Srinivasan Thomas Yegnasubramanian and William Andrew Nelson and Ah-Ng Kong},
  journal={Cancer prevention research},
  volume={7 12},
Epigenetic control of NRF2, a master regulator of many critical antioxidative stress defense genes in human prostate cancer (CaP), is unknown. Our previous animal study found decreased Nrf2 expression through promoter CpG methylation/histone modifications during prostate cancer progression in TRAMP mice. In this study, we evaluated CpG methylation of human NRF2 promoter in 27 clinical prostate cancer samples and in LNCaP cells using MAQMA analysis and bisulfite genomic DNA sequencing. Prostate… CONTINUE READING
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