Epigenetic Cross-Talk between DNA Methylation and Histone Modifications in Human Cancers

@inproceedings{Kondo2009EpigeneticCB,
  title={Epigenetic Cross-Talk between DNA Methylation and Histone Modifications in Human Cancers},
  author={Yutaka Kondo},
  booktitle={Yonsei medical journal},
  year={2009}
}
DNA methylation, histone modifications, and the chromatin structure are profoundly altered in human cancers. The silencing of cancer-related genes by these epigenetic regulators is recognized as a key mechanism in tumor formation. Recent findings revealed that DNA methylation and histone modifications appear to be linked to each other. However, it is not clearly understood how the formation of histone modifications may affect DNA methylation and which genes are relevantly involved with tumor… CONTINUE READING