Epigenetic Control of Skeletal Development by the Histone Methyltransferase Ezh2.

  title={Epigenetic Control of Skeletal Development by the Histone Methyltransferase Ezh2.},
  author={Amel Dudakovic and Emily T. Camilleri and Fuhua Xu and Scott M. Riester and Meghan E McGee-Lawrence and Elizabeth W Bradley and Christopher R. Paradise and Eric Lewallen and Raphael Thaler and David R. Deyle and Annalise Noelle Larson and David G. Lewallen and Allan B Dietz and Gary S Stein and Mart{\'i}n A. Montecino and Jennifer J Westendorf and Andre J van Wijnen},
  journal={The Journal of biological chemistry},
  volume={290 46},
Epigenetic control of gene expression is critical for normal fetal development. However, chromatin-related mechanisms that activate bone-specific programs during osteogenesis have remained underexplored. Therefore, we investigated the expression profiles of a large cohort of epigenetic regulators (>300) during osteogenic differentiation of human mesenchymal cells derived from the stromal vascular fraction of adipose tissue (AMSCs). Molecular analyses establish that the polycomb group protein… CONTINUE READING

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Chemical inhibitor and siRNA knockdown studies show that EZH2 , a histone methyltransferase that catalyzes trimethylation of histone 3 lysine 27 ( H3K27me3 ) , suppresses osteogenic differentiation .
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