Epigenetic Changes in Basal Cell Carcinoma Affect SHH and WNT Signaling Components

  title={Epigenetic Changes in Basal Cell Carcinoma Affect SHH and WNT Signaling Components},
  author={Tjinta Brinkhuizen and Karin van den Hurk and V{\'e}ronique J. L. Winnepenninckx and Joep P. J. de Hoon and Ari{\"e}nne M W van Marion and J{\"u}rgen Veeck and Manon van Engeland and Maurice A. M. van Steensel},
  booktitle={PloS one},
BACKGROUND The genetic background of Basal Cell Carcinoma (BCC) has been studied extensively, while its epigenetic makeup has received comparatively little attention. Epigenetic alterations such as promoter hypermethylation silence tumor suppressor genes (TSG) in several malignancies. OBJECTIVE We sought to analyze the promoter methylation status of ten putative (tumor suppressor) genes that are associated with Sonic Hedgehog (SHH), WNT signaling and (hair follicle) tumors in a large series… CONTINUE READING
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