Epigenetic Changes in Basal Cell Carcinoma Affect SHH and WNT Signaling Components

@inproceedings{Brinkhuizen2012EpigeneticCI,
  title={Epigenetic Changes in Basal Cell Carcinoma Affect SHH and WNT Signaling Components},
  author={Tjinta Brinkhuizen and Karin van den Hurk and V{\'e}ronique J. L. Winnepenninckx and Joep P. J. de Hoon and Ari{\"e}nne M W van Marion and J{\"u}rgen Veeck and Manon van Engeland and Maurice A. M. van Steensel},
  booktitle={PloS one},
  year={2012}
}
BACKGROUND The genetic background of Basal Cell Carcinoma (BCC) has been studied extensively, while its epigenetic makeup has received comparatively little attention. Epigenetic alterations such as promoter hypermethylation silence tumor suppressor genes (TSG) in several malignancies. OBJECTIVE We sought to analyze the promoter methylation status of ten putative (tumor suppressor) genes that are associated with Sonic Hedgehog (SHH), WNT signaling and (hair follicle) tumors in a large series… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 11 times over the past 90 days. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-9 of 9 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 57 references

Similar Papers

Loading similar papers…