Epigenetic CRBP downregulation appears to be an evolutionarily conserved (human and mouse) and oncogene-specific phenomenon in breast cancer

@article{Arapshian2003EpigeneticCD,
  title={Epigenetic CRBP downregulation appears to be an evolutionarily conserved (human and mouse) and oncogene-specific phenomenon in breast cancer},
  author={Alice Arapshian and Silvina P Bertran and Yuvarani S Kuppumbatti and Shigeo Nakajo and Rafael Mira-y-Lopez},
  journal={Molecular Cancer},
  year={2003},
  volume={3},
  pages={13 - 13}
}
The cellular retinol binding protein I gene (CRBP) is downregulated in a subset of human breast cancers and in MMTV-Myc induced mouse mammary tumors. Functional studies suggest that CRBP downregulation contributes to breast tumor progression. What is the mechanism underlying CRBP downregulation in cancer? Here we investigated the hypothesis that CRBP is epigenetically silenced through DNA hypermethylation in human and mouse breast cancer. Bisulfite sequencing of CRBP in a panel of 6 human… CONTINUE READING
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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

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  • Anal Biochem
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