Epigenetic Alterations in Human Liver From Subjects With Type 2 Diabetes in Parallel With Reduced Folate Levels.

@article{Nilsson2015EpigeneticAI,
  title={Epigenetic Alterations in Human Liver From Subjects With Type 2 Diabetes in Parallel With Reduced Folate Levels.},
  author={Emma Julia P. Nilsson and Ashok Matte and Alexander Perfilyev and Vanessa D de Mello and Pirjo K{\"a}kel{\"a} and Jussi Pihlajam{\"a}ki and Charlotte Ling},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2015},
  volume={100 11},
  pages={E1491-501}
}
OBJECTIVE Epigenetic variation may contribute to the development of complex metabolic diseases such as type 2 diabetes (T2D). Hepatic insulin resistance is a hallmark of T2D. However, it remains unknown whether epigenetic alterations take place in the liver from diabetic subjects. Therefore, we investigated the genome-wide DNA methylation pattern in the liver from subjects with T2D and nondiabetic controls and related epigenetic alterations to gene expression and circulating folate levels… CONTINUE READING
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