Epigallocathechin-3 gallate inhibits cardiac hypertrophy through blocking reactive oxidative species-dependent and -independent signal pathways.

@article{Li2006Epigallocathechin3GI,
  title={Epigallocathechin-3 gallate inhibits cardiac hypertrophy through blocking reactive oxidative species-dependent and -independent signal pathways.},
  author={Hongliang Li and Yue Huang and Chan-na Zhang and Guang Mang Liu and Yu-sheng Wei and Abi-Bing Wang and Yuqing Liu and Rui-tai Hui and Chiming Wei and Gary M Williams and De-Pei Liu and Chih-Chuan Liang},
  journal={Free radical biology & medicine},
  year={2006},
  volume={40 10},
  pages={1756-75}
}
Cardiac hypertrophy is a major cause of morbidity and mortality worldwide. Recent in vitro and in vivo studies have suggested that reactive oxygen species (ROS) may play an important role in cardiac hypertrophy. It was therefore thought to be of particular value to examine the effects of antioxidants on cardiac hypertrophy. Epigallocatechin-3-gallate (EGCG) is a major bioactive polyphenol present in green tea and a potent antioxidant. The current study was designed to test the hypothesis that… CONTINUE READING