Epigallocatechin gallate targeting of membrane type 1 matrix metalloproteinase-mediated Src and Janus kinase/signal transducers and activators of transcription 3 signaling inhibits transcription of colony-stimulating factors 2 and 3 in mesenchymal stromal cells.

@article{Zgheib2013EpigallocatechinGT,
  title={Epigallocatechin gallate targeting of membrane type 1 matrix metalloproteinase-mediated Src and Janus kinase/signal transducers and activators of transcription 3 signaling inhibits transcription of colony-stimulating factors 2 and 3 in mesenchymal stromal cells.},
  author={Alain Zgheib and Sylvie Lamy and Borhane Annabi},
  journal={The Journal of biological chemistry},
  year={2013},
  volume={288 19},
  pages={13378-86}
}
BACKGROUND CSF-2 and CSF-3 confer proangiogenic and immunomodulatory properties to mesenchymal stromal cells (MSCs). RESULTS Transcriptional regulation of CSF-2 and CSF-3 in concanavalin A-activated MSCs requires MT1-MMP signaling and is inhibited by EGCG. CONCLUSION The chemopreventive properties of diet-derived EGCG alter MT1-MMP-mediated… CONTINUE READING