Epigallocatechin gallate is a slow-tight binding inhibitor of enoyl-ACP reductase from Plasmodium falciparum.

@article{Banerjee2008EpigallocatechinGI,
  title={Epigallocatechin gallate is a slow-tight binding inhibitor of enoyl-ACP reductase from Plasmodium falciparum.},
  author={T. Banerjee and S. Sharma and N. Surolia and A. Surolia},
  journal={Biochemical and biophysical research communications},
  year={2008},
  volume={377 4},
  pages={
          1238-42
        }
}
Epigallocatechin gallate (EGCG) is known to have numerous pharmacological properties. In the present study, we have shown that EGCG inhibits enoyl-acyl carrier protein reductase of Plasmodium falciparum (PfENR) by following a two-step, slow, tight-binding inhibition mechanism. The association/isomerization rate constant (k(5)) of the reversible and loose PfENR-EGCG binary complex to a tight [PfENR-EGCG](*) or EI(*) complex was calculated to be 4.0x10(-2) s(-1). The low dissociation rate… Expand
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