Epigallocatechin-3-gallate promotes apoptosis in human breast cancer T47D cells through down-regulation of PI3K/AKT and Telomerase.

@article{Moradzadeh2017Epigallocatechin3gallatePA,
  title={Epigallocatechin-3-gallate promotes apoptosis in human breast cancer T47D cells through down-regulation of PI3K/AKT and Telomerase.},
  author={M. Moradzadeh and A. Hosseini and S. Erfanian and Hadi Rezaei},
  journal={Pharmacological reports : PR},
  year={2017},
  volume={69 5},
  pages={
          924-928
        }
}
BACKGROUND Green tea has antioxidant, anti-tumor and anti-bacterial properties. Epigallocatechin-3-gallate (EGCG) in green tea is highly active as a cancer chemopreventive agent. In this study, we designed a series of experiments to examine the effects of EGCG on proliferation and apoptosis of estrogen receptor α-positive breast cancer (T47D) cells. METHODS Cells were treated with EGCG (0-80μM) and tamoxifen (0-20μM), as the positive control, up to 72h. Cell viability was determined by MTT… Expand
Expression of genes modulated by epigallocatechin-3-gallate in breast cancer cells
The Role of EGCG in Breast Cancer Prevention and Therapy.
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