Epigallocatechin-3-gallate induced primary cultures of rat hippocampal neurons death linked to calcium overload and oxidative stress

@article{Yin2009Epigallocatechin3gallateIP,
  title={Epigallocatechin-3-gallate induced primary cultures of rat hippocampal neurons death linked to calcium overload and oxidative stress},
  author={Shu-Ting Yin and Ming-liang Tang and Hong-Min Deng and Tai-Ran Xing and Ju-tao Chen and Huili Wang and Di-yun Ruan},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={2009},
  volume={379},
  pages={551-564}
}
Epigallocatechin-3-gallate (EGCG), a catechin polyphenols component, is the main ingredient of green tea extract. It has been reported that EGCG is a potent antioxidant and beneficial in oxidative stress-related diseases, but others and our previous study showed that EGCG has pro-oxidant effects at high concentration. Thus, in this study, we tried to examine the possible pathway of EGCG-induced cell death in cultures of rat hippocampal neurons. Our results showed that EGCG caused a rapid… CONTINUE READING

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