Epigallocatechin-3-gallate enhances ischemia/reperfusion-induced apoptosis in human umbilical vein endothelial cells via AKT and MAPK pathways

@article{Zhang2009Epigallocatechin3gallateEI,
  title={Epigallocatechin-3-gallate enhances ischemia/reperfusion-induced apoptosis in human umbilical vein endothelial cells via AKT and MAPK pathways},
  author={Tianpeng Zhang and Dan Yang and Yongna Fan and Ping Xie and Huihua Li},
  journal={Apoptosis},
  year={2009},
  volume={14},
  pages={1245-1254}
}
  • Tianpeng Zhang, Dan Yang, +2 authors Huihua Li
  • Published in Apoptosis 2009
  • Medicine, Biology
  • Epigallocatechin-3-gallate (EGCG), the major constituent of green tea, has been shown to promote apoptosis in cancer cells. However, the role of EGCG in endothelial cells following ischemia/reperfusion (I/R) injury remains unclear. In the present study, we investigated the mechanisms by which EGCG enhances I/R-induced cell growth inhibition and apoptosis in human umbilical vein endothelial cells (HUVECs). Our results showed that EGCG treatment caused cell proliferation inhibition during I/R… CONTINUE READING

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