Epigallocatechin-3-gallate, a DYRK1A inhibitor, rescues cognitive deficits in Down syndrome mouse models and in humans.

@article{Torre2014Epigallocatechin3gallateAD,
  title={Epigallocatechin-3-gallate, a DYRK1A inhibitor, rescues cognitive deficits in Down syndrome mouse models and in humans.},
  author={Rafael de la Torre and Susana de Sola and Meritxell Pons and Arnaud Duchon and Mar{\'i}a Mart{\'i}nez de Lagr{\'a}n and Mag{\'i} Farr{\'e} and Montserrat Fito and Bessy Benejam and Klaus Langohr and Joan Pau Rodr{\'i}guez and Mitona Pujadas and Jean Charles Bizot and A. Calvo Cuenca and Nathalie Janel and Silvina Catuara and Maria-Isabel Covas and Henri Bl{\'e}haut and Yann H{\'e}rault and Jean Marie Delabar and Mara Dierssen},
  journal={Molecular nutrition & food research},
  year={2014},
  volume={58 2},
  pages={278-88}
}
SCOPE Trisomy for human chromosome 21 results in Down syndrome (DS), which is among the most complex genetic perturbations leading to intellectual disability. Accumulating data suggest that overexpression of the dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A (DYRK1A), is a critical pathogenic mechanisms in the intellectual deficit. METHODS AND RESULTS Here we show that the green tea flavonol epigallocatechin-gallate (EGCG), a DYRK1A inhibitor, rescues the cognitive deficits… CONTINUE READING

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