Epigallocatechin-3-gallate(EGCG) suppresses melanoma cell growth and metastasis by targeting TRAF6 activity

@inproceedings{Zhang2016Epigallocatechin3gallateEGCGSM,
  title={Epigallocatechin-3-gallate(EGCG) suppresses melanoma cell growth and metastasis by targeting TRAF6 activity},
  author={Jianglin Zhang and Zhou Lei and Zunnan Huang and Xu Zhang and Youyou Zhou and Zhongling Luo and Weiqi Zeng and Juan Su and Cong Peng and Xiang Ming Chen},
  booktitle={Oncotarget},
  year={2016}
}
TRAF6 (TNF Receptor-Associated Factor 6) is an E3 ubiquitin ligase that contains a Ring domain, induces K63-linked polyubiquitination, and plays a critical role in signaling transduction. Our previous results demonstrated that TRAF6 is overexpressed in melanoma and that TRAF6 knockdown dramatically attenuates tumor cell growth and metastasis. In this study… CONTINUE READING

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