Epigallocatechin‐3‐gallate inhibits TLR4 signaling through the 67‐kDa laminin receptor and effectively alleviates acute lung injury induced by H9N2 swine influenza virus

@article{Xu2017Epigallocatechin3gallateIT,
  title={Epigallocatechin‐3‐gallate inhibits TLR4 signaling through the 67‐kDa laminin receptor and effectively alleviates acute lung injury induced by H9N2 swine influenza virus},
  author={Ming-ju Xu and Bao-jian Liu and Cun-lian Wang and Guo-hua Wang and Yong Tian and Shaohua Wang and Jialiang Li and Pei-yao Li and Ruihua Zhang and Dong Wei and Shu-fei Tian and Tong Xu},
  journal={International Immunopharmacology},
  year={2017},
  volume={52},
  pages={24–33}
}
ABSTRACT Epigallocatechin‐3‐gallate (EGCG) was found to inhibit the Toll‐like receptor 4 (TLR4) pathway involved in influenza virus pathogenesis. Here, the effect of EGCG on TLR4 in an H9N2 virus‐induced acute lung injury mouse model was investigated. BALB/c mice were inoculated intranasally with A/Swine/Hebei/108/2002 (H9N2) virus or noninfectious allantoic fluid, and treated with EGCG and E5564 or normal saline orally for 5 consecutive days. PMVECs were treated with EGCG or anti‐67 kDa… CONTINUE READING
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