Epigallocatechin‐3‐O‐gallate up‐regulates microRNA‐199a‐3p expression by down‐regulating the expression of cyclooxygenase‐2 in stimulated human osteoarthritis chondrocytes

@inproceedings{Rasheed2016Epigallocatechin3OgallateUM,
  title={Epigallocatechin‐3‐O‐gallate up‐regulates microRNA‐199a‐3p expression by down‐regulating the expression of cyclooxygenase‐2 in stimulated human osteoarthritis chondrocytes},
  author={Zafar Rasheed and Naila Rasheed and Hani A. Al‐Shobaili},
  booktitle={Journal of cellular and molecular medicine},
  year={2016}
}
Osteoarthritis (OA) is a most common form of arthritis worldwide leading to significant disability. MicroRNAs (miRNAs) are non-coding RNAs involved in various aspects of cartilage development, homoeostasis and pathology. Several miRNAs have been identified which have shown to regulate expression of target genes relevant to OA pathogenesis such as matrix metalloproteinase (MMP)-13, cyclooxygenase (COX)-2, etc. Epigallocatechin-3-O-gallate (EGCG), the most abundant and active polyphenol in green… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 33 references

Gene regulation

  • E. Izaurralde
  • Breakers and blockers-miRNAs at work. Science
  • 2015
1 Excerpt

Similar Papers

Loading similar papers…