Epifil: a dynamic model of infection and disease in lymphatic filariasis.

  title={Epifil: a dynamic model of infection and disease in lymphatic filariasis.},
  author={Man-Suen Chan and A. Srividya and R A Norman and S. P. Pani and K. Dasaradh Ramaiah and Perumal Vanamail and Edwin Michael and Pradeep Kumar Das and Donald A. P. Bundy},
  journal={The American journal of tropical medicine and hygiene},
  volume={59 4},
The lack of a quantitative framework that describes the dynamic relationships between infection and morbidity has constrained efforts aimed at the community-level control of lymphatic filariasis. In this paper, we describe the development and validation of EPIFIL, a dynamic model of filariasis infection intensity and chronic disease. Infection dynamics are modeled using the well established immigration-death formulation, incorporating the acquisition of immunity to infective larvae over time… CONTINUE READING