Epidural clonidine treatment for refractory reflex sympathetic dystrophy.

  title={Epidural clonidine treatment for refractory reflex sympathetic dystrophy.},
  author={Richard L. Rauck and James C Eisenach and Karen Jackson and L. M. De Young and Jo Southern},
  volume={79 6},
  pages={1163-9; discussion 27A}
BACKGROUND Intraspinally administered alpha 2-adrenergic agonists may relieve pain in sympathetically maintained pain (SMP) syndromes, such as reflex sympathetically dystrophy (RSD), by spinal, peripheral, and central nervous system actions. This study examined analgesic efficacy and side effects of epidurally administered clonidine in patients with severe, refractory RSD. METHODS Twenty-six patients with severe chronic pain consistent with RSD were studied in a randomized, blinded, placebo… CONTINUE READING